Theoretical modeling and mechanism of drug release from controlled release implants by microstructural image characterization
US11900025B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Mar 4, 2019 |
| Grant date | Feb 13, 2024 |
| Priority date | — |
| Expiry date | Sep 4, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16C60/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Embodiments disclosed herein relate to a model for predicting the release profile of a controlled release device. The implant modeling system and models disclosed herein allow the accurate prediction of a release profile for a controlled release device based on features extracted from micro-resolution imagery. The models combine microstructural features that can be extracted at the XRCT resolution, including pore volume and connectivity, using erosion-dilation image analysis. This strategy allows prediction of release curves of the controlled release device using XRCT despite its resolution limitations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.