Patent · US Active

Fc variants and methods for their production

US11912773B2 · kind B2 · utility

0Cited by

80References

35Claims

0Family size

Assignee

Genentech, Inc. · US

Inventors

J. Michael Elliott · Rue de l'Église, US
Justin Scheer · San Francisco, US

Key dates

Filing date	May 12, 2020
Grant date	Feb 27, 2024
Priority date	—
Expiry date	Dec 29, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K16/468
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.