Patent · US Active

Method for determining the amount of a therapeutic antibody in the brain

US11913945B2 · kind B2 · utility

2Cited by

0References

14Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Martin Schaefer · Penzberg, DE
Sylvia Rottach · Penzberg, DE
Gregor Jordan · Penzberg, DE
Kay-Gunnar Stubenrauch · Frauenfeld, CH
Roland Staack · Penzberg, DE
Kevin Brady · Concord, US

Key dates

Filing date	Dec 29, 2020
Grant date	Feb 27, 2024
Priority date	—
Expiry date	Feb 2, 2041

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/52
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced by applying an inert reference antibody that does not penetrate into said tissue, whereby the inert reference antibody is administered 2 to 10 minutes prior to obtaining the tissue and blood sample.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.