Patent · US Active

Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography

US11945839B2 · kind B2 · utility

0Cited by

1References

17Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Thomas von Hirschheydt · Penzberg, DE
Petra Rueger · Penzberg, DE
Birgit Weydanz · Penzberg, DE
Hubert Hertenberger · Weilheim, DE

Key dates

Filing date	Dec 20, 2018
Grant date	Apr 2, 2024
Priority date	—
Expiry date	May 10, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/66
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to methods for separating multispecific CrossMab antibodies from light chain mispaired variants thereof in a solution comprising CrossMab bispecific antibodies and mispaired antibody variants thereof by hydrophobic interaction chromatography.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.