Preparation of benzimidazolone derivatives as novel diacylglyceride O-acyltransferase 2 inhibitors
US11976061B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 2021 |
| Grant date | May 7, 2024 |
| Priority date | — |
| Expiry date | Oct 6, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Invented are compounds of Formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I to a patient in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.