Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment

US11981922B2 · kind B2 · utility

Assignees

• DANA-FARBER CANCER INSTITUTE, INC. · US
• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Meromit Singer · Boston, US
• Aviv Regev · Cambridge, US
• Orit Rozenblatt-Rosen · Cambridge, US
• Davide Mangani · Boston, US
• Ana Carrizosa Anderson · Boston, US
• Vijay K. Kuchroo · Newton, US
• Linglin Huang · Boston, US

Key dates

• Filing date: Oct 5, 2020
• Grant date: May 14, 2024
• Expiry date: Dec 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is generally directed to identify interacting cells in the tumor microenvironment and using the identified interactions to enhance anti-tumor immunity in cancer. Identified interactions can be modulated using therapeutic agents. Immune cells resistant to suppression can be used for adoptive cell transfer. The present invention is also generally directed to cell types and genes that are correlated to time of tumor growth and tumor size.