Drug-conjugates with a targeting molecule and two different drugs

US11987622B2 · kind B2 · utility

Assignee

• Vivasor, Inc. · US

Inventors

• Zhenwei Miao · San Diego, US
• Gang Chen · Sammamish, US
• Tong Zhu · Johnston, US
• Alisher B. Khasanov · Carlsbad, US
• Yufeng Hong · San Diego, US
• Hong Zhang · San Diego, US
• Alexander Chucholowski · San Diego, US

Key dates

• Filing date: Sep 29, 2020
• Grant date: May 21, 2024
• Expiry date: Apr 10, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.