Stem cell derived pancreatic islet differentiation

US11992506B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• George Harb · Boston, US
• Chunhui Xie · Laishui, CN
• Bryce W. Carey · New York, US
• Aleksander Szymaniak · Boston, US
• Christopher Thanos · Cumberland, US
• Evrett Thompson · Woburn, US
• Rebecca Chinn · Boston, US
• Suyash Raj · Boston, US

Key dates

• Filing date: Nov 1, 2022
• Grant date: May 28, 2024
• Expiry date: Nov 1, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.