Patent · US Active

Covalently linked antigen-antibody conjugates

US12023378B2 · kind B2 · utility

0Cited by

94References

21Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Joerg Benz · Rheinfelden (Baden), DE
Ulrich Brinkmann · Weilheim, DE
Stefan Dengl · Munich, DE
Sebastian Dziadek · Basel, CH
Guy Georges · Habach, DE
Michael Grote · Penzberg, DE
Alexander Haas · Munich, DE
Eike Hoffmann · Viernheim, DE

Key dates

Filing date	Oct 29, 2019
Grant date	Jul 2, 2024
Priority date	—
Expiry date	Dec 19, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.