Gastric residence systems with release rate-modulating films

US12023406B2 · kind B2 · utility

Assignee

• LYNDRA THERAPEUTICS, INC. · US

Inventors

• Rosemary KANASTY · Somerville, US
• Nupura BHISE · Baltimore, US
• Stephen E. Zale · Hopkinton, US
• Bennett Carter · Stoughton, US
• Jung Hoon YANG · Brookline, US
• Andrew Bellinger · Wellesley, US
• Susan Low · Pepperell, US
• James Wright · Lompoc, US
• David Altreuter · Wayland, US
• Colin R. Gardner · Lawrence, US

Key dates

• Filing date: Jun 8, 2018
• Grant date: Jul 2, 2024
• Expiry date: Feb 15, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides gastric residence systems, or components of gastric residence system such as segments or elongate members of gastric residence systems, with release rate-modulating films and methods for making and using such systems. The release rate-modulating films provide good control over release of agents (such as therapeutic, diagnostic, or nutritional agents) present in the gastric residence system. The films also permit higher drug loading in the gastric residence systems and components of gastric residence systems while maintaining good control over release of agents. Some embodiments of the films can provide resistance against burst release of agent upon exposure to alcohol.