Methods, devices, and systems for analyte detection and analysis
US12031180B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 6, 2021 |
| Grant date | Jul 9, 2024 |
| Priority date | — |
| Expiry date | Jan 22, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N35/1002
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.