Enzymatic synthesis of 4′-ethynyl nucleoside analogs
US12037623B2 · kind B2 · utility
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27Claims
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Key dates
| Filing date | Jul 2, 2019 |
| Grant date | Jul 16, 2024 |
| Priority date | — |
| Expiry date | Jan 31, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.