Patent · US Active

Differentiation of pancreatic endocrine cells

US12049645B2 · kind B2 · utility

5Cited by

13References

33Claims

0Family size

Assignee

Vertex Pharmaceuticals Incorporated · US

Inventors

George Harb · Boston, US
Chunhui Xie · Laishui, CN

Key dates

Filing date	Jul 30, 2021
Grant date	Jul 30, 2024
Priority date	—
Expiry date	Jul 30, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2501/415
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.