Compounds, compositions and methods for cancer patient stratification and cancer treatment

US12053476B2 · kind B2 · utility

Assignees

• Bayer Pharma Aktiengesellschaft · DE
• The Broad Institute, Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Timothy A. Lewis · Marlborough, US
• Alex Burgin · Cambridge, US
• Monica Schenone · Sharon, US
• Xiaoyun Wu · Chesterfield, US
• Heidi Greulich · Cambridge, US
• Matthew Meyerson · Concord, US
• Luc De Waal · Medford, US
• Antje Margret Wengner · Berlin, DE
• Knut Eis · Berlin, DE
• Philip Lienau · Berlin, DE
• Ulrike Sack · Berlin, DE
• Martin Lange · Berlin, DE

Key dates

• Filing date: Jan 28, 2021
• Grant date: Aug 6, 2024
• Expiry date: Jun 27, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features improved compounds, especially methods of identifying patients having cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3L1) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).