Light microscope with photon-counting detector elements and imaging method

US12055700B2 · kind B2 · utility

Assignee

• Carl Zeiss Microscopy GmbH · DE

Inventors

• Tiemo Anhut · Jena, DE
• Daniel Schwedt · Weimar, DE
• Ivan Michel Antolovic · Lausanne, CH
• Claudio Bruschini · Villars-sous-Yens, CH
• Edoardo Charbon · The Hague, NL

Key dates

• Filing date: Jan 25, 2019
• Grant date: Aug 6, 2024
• Expiry date: Jun 18, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G02B21/008
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A light microscope has a light source for illuminating a specimen, a photon-counting detector array with a plurality of photon-counting detector elements for measuring detection light coming from the specimen, wherein the photon-counting detector elements are configured to output respective measured photon count rates, and a control device for controlling the photon-counting detector array. The control device is configured to individually influence the measurable photon count rates which are simultaneously measurable with different photon-counting detector elements and/or which are consecutively measurable with the same photon-counting detector element. Furthermore, in an imaging method the measurable photon count rates of photon-counting detector elements are individually influenced to increase the signal-to-noise ratio for the photon-counting detector array.