Phenoxy-pyridyl-pyrimidine compounds and methods of use
US12071425B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Sep 12, 2019 |
| Grant date | Aug 27, 2024 |
| Priority date | — |
| Expiry date | Oct 27, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.