Chimeric vectors

US12071632B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Shirin Munir · Bethesda, US
• Linda G. Brock · Wyckoff, US
• Ursula Buchholz · Silver Spring, US
• Peter L. Collins · Kensington, US

Key dates

• Filing date: Apr 23, 2019
• Grant date: Aug 27, 2024
• Expiry date: Oct 29, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18551
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are live, chimeric non-human Mononegavirales vectors that allow a cell to express at least one protein from at least one human pathogen. In addition, compositions comprising the vectors, methods and kits for eliciting an immune response in a host, and methods of making the vectors are disclosed, in accordance with embodiments of the invention.