Variants of terminal deoxynucleotidyl transferase and uses thereof
US12071638B2 · kind B2 · utility
1Cited by
36References
22Claims
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Key dates
| Filing date | Dec 7, 2021 |
| Grant date | Aug 27, 2024 |
| Priority date | — |
| Expiry date | Apr 4, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y207/07031
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to variants of Terminal deoxynucleotidyl Transferase (TdT), each of which (i) has an amino acid sequence similarity to SEQ ID NO: 2. 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33 or 35 with corresponding amino acid substitutions, (ii) is capable of synthesizing a nucleic acid fragment without a template and (iii) is capable of incorporating a modified nucleotide into the nucleic acid fragment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.