Methods and systems for predicting response to PD-1 axis directed therapeutics
US12086985B2 · kind B2 · utility
0Cited by
0References
43Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Mar 30, 2021 |
| Grant date | Sep 10, 2024 |
| Priority date | — |
| Expiry date | Mar 15, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30096
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.