Compositions of programmed death receptor 1 (PD-1) antibodies and methods of obtaining the compositions thereof
US12110330B2 · kind B2 · utility
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32Claims
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Key dates
| Filing date | Jan 27, 2022 |
| Grant date | Oct 8, 2024 |
| Priority date | — |
| Expiry date | Jan 27, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8518
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0% oxidation of Met105 in the CDRH3 heavy chain region, and methods of obtaining the purified compositions. The invention also provides compositions comprising anti-PD-1 antibody main species and acidic species thereof, wherein the amount of acidic species is about 1.0-12.0%.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.