Process for the preparation of intermediates useful for making (2S,5R)-7-oxo-n-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide

US12162883B2 · kind B2 · utility

Assignees

• Merck Sharp & Dohme LLC · US
• Merck Sharp & Dohme (UK) · GB

Inventors

• John Y. L. Chung · Edison, US
• Tetsuji Itoh · Raritan, US
• Jungchul Kim · Berkeley Heights, US
• Jacob H. Waldman · Metuchen, US
• Debra Jane Wallace · Vancouver, CA
• Andrew M. Wood · Bridgeport, US
• Feng Xu · Durham, US
• Andrew Gibson · Welwyn Garden City, GB
• Jeremy Scott · Hertford, GB

Key dates

• Filing date: Apr 21, 2020
• Grant date: Dec 10, 2024
• Expiry date: Feb 15, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/96
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention is related to the preparation of protected piperidine carboxylates suitable for use as intermediates that lead, via a series of additional process steps, including a sulfation of a hydroxy urea compound, to the preparation of the beta lactamase inhibitor (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide.