Salts and polymorphs of certain MCL-1 inhibitors

US12162896B2 · kind B2 · utility

Assignee

• Gilead Sciences, Inc. · US

Inventors

• John Enquist · San Mateo, US
• Michael A. Ischay · Madison, US
• Olga Viktorovna Lapina · Newark, US
• David W. Lin · Berkeley, US
• Christopher S. Regens · San Francisco, US
• David A. Siler · San Mateo, US
• Eric A. Standley · Foster City, US
• Sarah WORTMAN · San Mateo, US

Key dates

• Filing date: May 3, 2023
• Grant date: Dec 10, 2024
• Expiry date: May 3, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates salts and the crystalline forms of certain 3′,4,4′,5-tetrahydro-2H,2′H-spiro[benzo[b][1,4]oxazepine-3,1′-naphthalene] derivatives as well as pharmaceutical formulations and therapeutic uses thereof. The present disclosure also relates to preparing such salts, crystalline forms and pharmaceutical formulations.