Binary lipid bilayer-containing vesicles comprising embedded cytotoxic agents and methods of making and using the same

US12178907B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Anu Puri · Frederick, US
• Mathias D. Viard · Frederick, US

Key dates

• Filing date: Jul 11, 2019
• Grant date: Dec 31, 2024
• Expiry date: Feb 6, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall.