Spirotricycle RIPK1 inhibitors and methods of uses thereof

US12180226B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Abdelghani Achab · Melrose, US
• Zachary G. Brill · Boston, US
• Jenny Lorena Rico Duque · Canton, US
• Xavier Fradera · Brookline, US
• Joey L. Methot · Westwood, US
• Phieng Siliphaivanh · Newton, US
• Jing Su · Scotch Plains, US
• Brandon A. Vara · Boston, US
• Erin F. Dimauro · Cambridge, US

Key dates

• Filing date: Oct 25, 2022
• Grant date: Dec 31, 2024
• Expiry date: Oct 25, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, W, X, Y, Z, m, n and p are as defined herein. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases.