Patent · US Active

Micromolecular compound specifically degrading tau protein, and application thereof

US12186400B2 · kind B2 · utility

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10Claims
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Assignee

Inventor

Key dates

Filing dateNov 9, 2018
Grant dateJan 7, 2025
Priority date—
Expiry dateMar 12, 2041

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D417/14
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The present disclosure discloses a micromolecular compound specifically degrading tau protein, and an application thereof. The chemical structure of the micromolecular compound specifically degrading tau protein is TBM-L-ULM or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph or N-oxide thereof, TBM being a tau protein-binding moiety, L being a linking group, and ULM being a ubiquitin ligase-binding moiety, the tau protein-binding moiety and the ubiquitin ligase-binding moiety being connected by means of the linking group. The micromolecular compound specifically degrading tau protein may increase tau protein degradation in a cell, thereby decreasing tau protein content.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.