Proximity-dependent biotinylation and uses thereof
US12188059B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Sep 13, 2017 |
| Grant date | Jan 7, 2025 |
| Priority date | — |
| Expiry date | Mar 15, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B20/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides fusion proteins, polynucleotides, kits, as well as TALE- or CRISPR-Cas based systems and methods. The present invention relies on proximity-dependent biotinylation, which allows site-directed protein or DNA purification and identification. The present invention provides tools for delineating the genetics of disease mechanism and for the identification of therapeutic targets and markers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.