Substituted pyrazolo piperidine carboxylic acids

US12195448B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Alexandros Vakalopoulos · Hilden, DE
• Marie-Pierre Collin-Kröpelin · Wuppertal, DE
• Nuria ORTEGA HERNANDEZ · Wuppertal, DE
• Andre DIESKAU · Wuppertal, DE
• Melissa BOULTADAKIS-ARAPINIS · Düsseldorf, DE
• Lisa CANDISH · Wuppertal, DE
• Timo Stellfeld · Berlin, DE
• Ilka MATHAR · Düsseldorf, DE
• Lucas Hudson HOFMEISTER · Wuppertal, DE
• Peter Sandner · Wuppertal, DE
• Frank Wunder · Wuppertal, DE
• Lisa DIETZ · Wuppertal, DE
• Robert Alan WEBSTER · Berlin, DE
• Carsten Schmeck · Wuppertal, DE
• Thomas MONDRITZKI · Essen, DE

Key dates

• Filing date: Apr 13, 2023
• Grant date: Jan 14, 2025
• Expiry date: Apr 13, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).