Antigen binding molecules comprising a trimeric TNF family ligand and encoding polynucleotides thereof
US12202870B2 · kind B2 · utility
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40Claims
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Key dates
| Filing date | Nov 18, 2021 |
| Grant date | Jan 21, 2025 |
| Priority date | — |
| Expiry date | Nov 18, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.