Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof
US12208088B2 · kind B2 · utility
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Key dates
| Filing date | Mar 17, 2021 |
| Grant date | Jan 28, 2025 |
| Priority date | — |
| Expiry date | Feb 15, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.