RNA-targeting system

US12215326B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US

Inventors

• Feng Zhang · Greenbelt, US
• Patrick Hsu · Cambridge, US
• Jonathan Gootenberg · Cambridge, US
• Aaron Smargon · Cambridge, US

Key dates

• Filing date: Jun 23, 2017
• Grant date: Feb 4, 2025
• Expiry date: Jun 23, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/22
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered RNA-targeting system comprising an RNA-targeting Cas protein and at least one RNA-targeting guide RNA, wherein said RNA-targeting guide RNA is capable of hybridizing with a target RNA in a cell.