Nucleic acid modifiers
US12227742B2 · kind B2 · utility
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50References
26Claims
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Key dates
| Filing date | Oct 23, 2018 |
| Grant date | Feb 18, 2025 |
| Priority date | — |
| Expiry date | Feb 26, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide a synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.