Differentiation of pancreatic endocrine cells

US12227765B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• George Harb · Boston, US
• Chunhi Xie · Belmont, US

Key dates

• Filing date: Sep 4, 2024
• Grant date: Feb 18, 2025
• Expiry date: Sep 4, 2044

Classification

• Technology area (CPC —): General

Abstract

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.