Therapeutic treatment of microsatellite unstable cancers

US12246004B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• INSTITUTO CARLOS SLIM DE LA SALUD, A.C. · MX
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Francisca Vazquez · Cambridge, US
• Adam Bass · Somerville, US
• Tsukasa Shibue · Cambridge, US
• Edmond Chan · Boston, US
• James McFarland · Torrance, US
• Mahmoud Ghandi · Cambridge, US
• Aviad Tsherniak · Cambridge, US

Key dates

• Filing date: Jun 3, 2019
• Grant date: Mar 11, 2025
• Expiry date: Mar 26, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of microsatellite unstable cancers. In particular, the instant disclosure provides for identification of a cancer as exhibiting microsatellite instability (MSI) and/or impaired mismatch repair (MMR), and selection and/or administration of an inhibitor of the WRN helicase as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.