4-amino or 4-alkoxy-substituted aryl sulfonamide compounds with selective activity in voltage-gated sodium channels

US12246008B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Christopher James Bungard · Lansdale, US
• Helen Chen · Livingston, US
• Jason M. Cox · Rancho Santa Fe, US
• Liangqin Guo · Edison, US
• Michael J. Kelly, III · Paoli, US
• Ronald Kim · Essen, DE
• Mark E. Layton · Harleysville, US
• Hong Liu · Seattle, US
• Jian Liu · Xi'an, CN
• Mehul Patel · Blue Bell, US
• James J. Perkins · Nazareth, US
• Deping Wang · Furlong, US
• Walter Won · Alpine, US
• Younong Yu · East Brunswick Township, US
• Ting Zhang · Princeton Junction, US

Key dates

• Filing date: Dec 2, 2019
• Grant date: Mar 11, 2025
• Expiry date: Jan 31, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.