Patent · US Active

Stabilized immunoglobulin domains

US12258371B2 · kind B2 · utility

0Cited by

8References

10Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Laura Deak Codarri · Schlieren, CH
Stefan Dengl · Munich, DE
Jens Fischer · Penzberg, DE
Thomas Hofer · Zürich, CH
Laurent Lariviere · Ostendorf, DE
Ekkehard Moessner · Kreuzlingen, CH
Stefan Seeber · Penzberg, DE
Pablo Umana · Wollerau, CH
Anne-Claire Zagdoun · Schlieren, CH

Key dates

Filing date	Jul 30, 2020
Grant date	Mar 25, 2025
Priority date	—
Expiry date	Oct 25, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/94
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates autonomous VH domains (aVH) with cysteines in positions 52a and 71 or in positions 33 and 52 in order to stabilize the autonomous VH domains. Said cysteines are capable of forming a disulfide bond and/or form a disulfide bond under suitable conditions. The invention further relates to aVH libraries.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.