Modulators of cystic fibrosis transmembrane conductance regulator

US12269831B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Jeremy J. Clemens · San Diego, US
• Brett C. Bookser · San Diego, US
• Thomas Cleveland · San Diego, US
• Timothy Richard Coon · Carlsbad, US
• Michel Gallant · Montréal, CA
• Peter Diederik Jan Grootenhuis · San Diego, US
• Sara S. Hadida Ruah · Village of La Jolla, US
• Julie Laterreur · San Diego, US
• Vito Melillo · Escondido, US
• Mark Miller · San Diego, US
• Prasuna Paraselli · San Diego, US
• Yeeman K. Ramtohul · ᐙᔂᓂᐲ Waswanipi, CA
• Thumkunta Jagadeeswar Reddy · Mont-Laurier, CA
• Claudio Sturino · Montréal, CA
• Lino Valdez · Carlsbad, US
• Jinglan Zhou · San Diego, US
• Minson Baek · San Diego, US
• William Schulz Bechara · Laval, CA

Key dates

• Filing date: Aug 6, 2021
• Grant date: Apr 8, 2025
• Expiry date: Jul 18, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.