Substituted tetrahydroquinolin compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors

US12275729B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Yongqi Deng · Newton, US
• Abdelghani Achab · Melrose, US
• David Jonathan Bennett · Watertown, US
• Indu T. Bharathan · Somerville, US
• Xavier Fradera · Brookline, US
• Craig R. Gibeau · Holliston, US
• Yongxin Han · Kirkland, CA
• Derun Li · Dedham, US
• Kun Liu · Edison, US
• Qinglin Pu · Needham, US
• Sulagna Sanyal · Belmont, US
• David L. Sloman · Brookline, US
• Wensheng Yu · Edison, US
• Hongjun Zhang · Waterloo, CA

Key dates

• Filing date: Oct 29, 2018
• Grant date: Apr 15, 2025
• Expiry date: Oct 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.