Enhancing immunogenicity of Streptococcus pneumoniae polysaccharide-protein conjugates
US12295998B2 · kind B2 · utility
0Cited by
12References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 22, 2023 |
| Grant date | May 13, 2025 |
| Priority date | — |
| Expiry date | Jun 22, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6037
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.