Patent · US Active

Method for generating multispecific antibodies from monospecific antibodies

US12297290B2 · kind B2 · utility

0Cited by

28References

15Claims

0Family size

Assignee

Hoffmann-La Roche Inc. · US

Inventors

Ulrich Brinkmann · Weilheim, DE
Stefan Dengl · Munich, DE
Guy Georges · Habach, DE
Eike Hoffmann · Viernheim, DE
Klaus Mayer · Prien am Chiemsee, DE
Felix Bormann · Penzberg, DE

Key dates

Filing date	Apr 15, 2020
Grant date	May 13, 2025
Priority date	—
Expiry date	Dec 5, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/66
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Herein is reported a method for the generation of multispecific antibodies by a half-antibody exchange reaction between two 2/3-IgGs destabilized in one half by asymmetric perturbing mutations fostering the generation of correctly assemble full length bispecific antibodies. The method can be performed in the absence of reducing agents and does not require hinge region disulfide bonds in the starting 2/3-IgGs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.