Diagnostic and therapeutic methods for the treatment of rheumatoid arthritis (RA)
US12319965B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 23, 2020 |
| Grant date | Jun 3, 2025 |
| Priority date | — |
| Expiry date | Oct 13, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides prognostic, predictive, and therapeutic methods for the treatment of rheumatoid arthritis (RA). The invention is based, at least in part, on the discovery that the expression level of one or more biomarkers described herein in a sample (e.g., a synovial tissue sample, a synovial fluid sample, or a combination thereof) from an individual having RA can be used in methods of determining whether an individual having RA is likely to exhibit disease progression, identifying an individual having RA who is likely to respond to a treatment including a disease modifying anti-rheumatic drug (DMARD), predicting responsiveness of an individual having RA to a treatment including a DMARD, selecting a therapy for an individual having RA, and treating an individual having RA, as well as related kits.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.