Methods of preparing macrocyclic indoles

US12338250B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• BAYER HEALTHCARE LLC · DE

Inventors

• Kai Thede · Leverkusen, DE
• Sven Wittrock · Berlin, DE
• Anne Mengel · Berlin, DE
• David McKinney · Cambridge, US
• Christopher Lemke · Laval, CA
• Steven James Ferrara · Cambridge, US
• Laura Furst · Cambridge, US
• Guo Ping Wei · Richmond, US
• Patrick R. McCarren · Cambridge, US

Key dates

• Filing date: May 15, 2020
• Grant date: Jun 24, 2025
• Expiry date: Jun 5, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to methods of preparing substituted indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, and intermediate compounds useful for preparing said compounds. These compounds are useful for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.