Factor XII (hageman factor) (F12), kallikrein B, plasma (fletcher factor) 1 (KLKB1), and kininogen 1 (KNG1) iRNA compositions and methods of use thereof
US12338439B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Jul 5, 2023 |
| Grant date | Jun 24, 2025 |
| Priority date | — |
| Expiry date | Jul 5, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/344
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) gene, the Factor XII (Hageman Factor (F12) gene, or the Kininogen 1 (KNG1) gene, and methods of using such RNAi agents to inhibit expression of a KLKB1 gene, an F12 gene, and/or a KNG1 gene, and methods of treating subjects having an hereditary angioedema (HAE) and/or a contact activation pathway-associated disorder.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.