COVID-19 vaccine

US12344635B2 · kind B2 · utility

Assignees

• The Medical College of Wisconsin, Inc. · US
• Wisconsin Alumni Research Foundation · US

Inventors

• Joseph T. Barbieri · Milwaukee, US
• Amanda Przedpelski · Milwaukee, US
• Eric A. Johnson · Hudson, US
• Sabine Pellett · Madison, US
• William H. Tepp · Stoughton, US

Key dates

• Filing date: Mar 24, 2021
• Grant date: Jul 1, 2025
• Expiry date: May 2, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/20034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are antigenic peptides comprising the SARS-COV-2 spike protein receptor binding domain (CRBD) polypeptide or portions thereof, linked to a non-catalytic, non-toxic tetanus toxin variant (i.e., a modified tetanus toxin or “MTT”) and vaccine compositions comprising the same. In addition, provided herein are methods for making and using CRBD-MTT fusion proteins as immunogenic agents.