CPF1 complexes with reduced indel activity

US12344838B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• Massachusetts Institute of Technology · US

Inventors

• Feng Zhang · Cambridge, US
• Bernd Zetsche · Cambridge, US
• Winston X. Yan · Brookline, US
• Neville Espi Sanjana · New York, US
• Sara Jones · Des Plaines, US

Key dates

• Filing date: Feb 7, 2022
• Grant date: Jul 1, 2025
• Expiry date: Jan 20, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y305/04005
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.