Multispecific antibodies targeting multiple epitopes on the HIV-1 envelope

US12365722B2 · kind B2 · utility

Assignees

• UNIVERSITY OF MARYLAND, COLLEGE PARK · US
• UNIVERSITY OF MARYLAND, BALTIMORE · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• International AIDS Vaccine Initiative, Inc. · US

Inventors

• Yuxing Li · Boyds, US
• James STEINHARDT · Westminster, US
• Javier Guenaga · New York, US
• John Mascola · Rockville, US
• Tae-Wook Chun · North Bethesda, US
• Susan Moir · Washington, US
• Chi-I Chiang · Rockville, US

Key dates

• Filing date: Oct 18, 2019
• Grant date: Jul 22, 2025
• Expiry date: Apr 30, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a multispecific anti-HIV antibody that binds to multiple epitopes on HIV envelope protein, wherein the antibody comprises: i. an amino acid sequence that binds to a V1/V2 apex glycan epitope; ii. an amino acid sequence that binds to a V3-base glycan region epitope; iii. an amino acid sequence that binds to a CD4 binding site (CD4bs) epitope; iv. an amino acid sequence that binds to a gp120/gp41 interface epitope; and v. an amino acid sequence that binds to a membrane proximal external region (MPER) epitope.