Cell-based treatment and drug discovery in Hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages
US12371662B2 · kind B2 · utility
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Key dates
| Filing date | Jun 22, 2018 |
| Grant date | Jul 29, 2025 |
| Priority date | — |
| Expiry date | Jun 22, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells into enteric neural crest lineage cells, and enteric neural crest lineage cells by such methods. The presently disclosed subject matter also provides for uses of such enteric neural crest lineage cells for preventing and/or treating enteric nervous system disorders (e.g, Hirschsprung's disease), and for screening compounds suitable for preventing and/or treating enteric nervous system disorders (e.g., Hirschsprung's disease).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.