Inhibitors of RNA-guided nuclease target binding and uses thereof

US12391685B2 · kind B2 · utility

Assignees

• The Broad Institute, Inc. · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Amit Choudhary · Boston, US
• Basudeb Maji · Boston, US
• Soumyashree Ashok Gangopadhyay · Boston, US
• Miseon Lee · Cambridge, US
• Mengchao Shi · Boston, US

Key dates

• Filing date: Aug 20, 2019
• Grant date: Aug 19, 2025
• Expiry date: Jun 26, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/99
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions are included. Methods of treatment using the inhibitory compounds, formulations and methods are also detailed, as well as control of nucleic acid editing systems and methods using said compounds.