Method for producing bispecific antibodies comprising a Y436A Fc-region mutation for improved protein A-binding
US12398203B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Dec 12, 2022 |
| Grant date | Aug 26, 2025 |
| Priority date | — |
| Expiry date | Dec 30, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein the first, the second, or the first and the second polypeptide comprise the mutation Y436A (numbering according to the EU index).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.