4H-pyrrolo[3,2-c]pyridin-4-one derivatives

US12403135B2 · kind B2 · utility

Assignees

• BAYER HEALTHCARE LLC · DE
• The Broad Institute, Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Franziska SIEGEL · Cambridge, US
• Daniel Korr · Berlin, DE
• Jens SCHRÖDER · Jena, DE
• Stephan Siegel · Berlin, DE
• Heidi Greulich · Cambridge, US
• Bethany Kaplan · Cambridge, US
• Matthew Meyerson · Concord, US

Key dates

• Filing date: Apr 22, 2020
• Grant date: Sep 2, 2025
• Expiry date: Oct 5, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) for use in the treatment or prophylaxis of a disease, which is a hyperproliferative disease and/or a disorder responsive to induction of cell death, selected from a haematological tumour, a solid tumour and/or metastases thereof, said tumour harbouring a mutant EGFR with exon 19 or 21 mutations, and their use as pharmaceuticals.