Method and apparatus for suprachoroidal administration of therapeutic agent

US12409064B2 · kind B2 · utility

Assignee

• Genentech, Inc. · US

Inventors

• Brendan J. Oberkircher · Cincinnati, US
• Daniel W. Price · Loveland, US
• Michael F. Keane · North Wales, US
• Saeed Sokhanvar · Medfield, US
• Daniel J. Yasevac · Somerville, US
• Michel Bruehwiler · Newton, US
• Leah R. Soffer · Somerville, US
• Isaac J. Khan · Bound Brook, US
• Benjamin L. Ko · Cincinnati, US
• Christopher D. Riemann · Cincinnati, US
• Nathan D. Grubbs · West Chester, US

Key dates

• Filing date: Apr 17, 2024
• Grant date: Sep 9, 2025
• Expiry date: Apr 17, 2044

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2210/0612
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy incision to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.